EDP Sciences 1776285484 20260415 fre

laboutique.edpsciences.fr-002219 03 01 01 002219 03 9782759830817 15 9782759830817 00 BA 02 16 mm 01 24 mm 10 01 02 Current Natural Sciences 01 01 Exercise book on Aromatic Nitrogen Heterocycles Chemistry How to deal with the synthesis and reactivity of five- and six-membered rings 1 A01 01 A2104 Sabine Chierici Chierici, Sabine Sabine Chierici Sabine Chierici est enseignant-chercheur au département de chimie moléculaire de l’université Grenoble Alpes. Sabine Chierici is a teacher-researcher in the department of molecular chemistry at the Grenoble Alpes University. 2 A01 01 A2103 Martine Demeunynck Demeunynck, Martine Martine Demeunynck Martine Demeunynck est Directrice de Recherches au CNRS, auDépartement de Pharmacochimie Moléculaire de l'Université Grenoble Alpes.<o:p></o:p> Martine Demeunynck is Director ofResearch at the CNRS, in the Department of Molecular Pharmacochemistry at theGrenoble Alpes University .<o:p></o:p><o:p> </o:p> 01 eng 00 230 03 02 24 Izibook:Subject Chimie 24 Izibook:SubjectAndCategoryAndTags |Chimie| 20 chemistry;exercise;exercises;exercise book;metal catalyzed pathways;five-membered rings;six-membered rings;electrophilic aromatic substitution;organimetallic reaction;complex polycyclic heterocycles 10 2011 SCI013040 01 540 05 06 03 00 <blockquote>Heterocyclic chemistry is one of the largest branches of chemistry. Heterocycles play major roles in important fields such as medicinal and pharmaceutical chemistries, agrochemicals or polymers. A good understanding of the comparative reactivity of simple five- and six-membered rings, i.e. pyrrole vs pyridine type rings, makes it possible to approach or predict the reactivity of more complex heterocycles. This book is a compilation of exercises, mostly adapted from published works. For more clarity we have chosen to limit ourselves to nitrogen containing heterocycles. The book is mainly aimed to Master students, but it will also be of interest for anyone who wants to train in this important field of synthetic chemistry. The book is organized in five sections. In the first chapter, typical syntheses along with metal catalyzed pathways are presented. The two following chapters are devoted to the chemical reactivity of the six-membered (pyridine, quinoline, azines) and five-membered rings (pyrrole, indole, azoles). In these two chapters, the exercises of increasing difficulties focus on the main types of reactions, including electrophilic and nucleophilic aromatic substitutions, N-alkylation and N-arylation, lithiation and other organometallic reactions, and metal catalyzed cross-coupling reactions. In the fourth chapter, the principles discussed in the previous chapters will be applied to the chemistry of complex polycyclic heterocycles containing both five and six membered rings (pyrrolyl-pyridine, aza-indole, indolizine, purine). The exercise solutions are commented in a separate chapter at the end of the book. Basic notions of nomenclature are given in a short appendix, allowing students to find out a ring structure from its name.</blockquote> 02 00 This book is a compilation of exercises, mostly adapted from published works, with commented solutions. The scope is voluntarily limited to nitrogen containing heterocycles. This book is a compilation of exercises, mostly adapted from published works, with commented solutions. The scope is voluntarily  limited to nitrogen containing heterocycles. 04 00 Abréviations.................................................................. .................................................. ...............7<o:p></o:p>Chapitre 1 Synthèses ................................................................ .................................................. ....11<o:p></o:p>1.1Les points-clés à retenir.................................................. .......................................11<o:p></o:p>1.2 Synthèses non catalysées par des métaux ....................................................... 13<o:p></o:p>1.3 Synthèses catalysées par des métaux ........................................................................24<o:p></o:p>Chapitre 2 Réactivité des hétérocycles à six chaînons...................................................... 35<o:p></o:p>2.1Points-clés à retenir ........................................................................................35<o:p></o:p>2.2 Réactions typiques......................................................................................36<o:p></o:p>2.3 Applications aux hétérocycles d'intérêt – Synthèses multi-étapes......................... 53<o:p></o:p>Chapitre 3 Réactivité des hétérocycles à cinq chaînons......................................... ...... 57<o:p></o:p>3.1Points-clés à retenir..............................................................................................57<o:p></o:p>3.2 Réactions typiques............................................................................................58<o:p></o:p>3.3 Applications aux hétérocycles d'intérêt – Synthèses multi-étapes............................ 68<o:p></o:p>Chapitre 4 Réactivité des polyhétérocycles contenant à la fois des cycles à cinq <span lang="EN-US" style="font-size:11.0pt;line-height:107%;font-family:"Calibri",sans-serif;mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:"Times New Roman";mso-bidi-theme-font:minor-bidi;mso-ansi-language:EN-US;mso-fareast-language:EN-US;mso-bidi-language:AR-SA">[1] et à six chaînons.................................73<o:p></o:p>4.1Points-clés à retenir.................................................................................73<o:p></o:p>4.2 Réactions...................................................................74<o:p></o:p>Chapitre 5 Réponses ..................................................................................99<o:p></o:p>5.1Synthèses........................................................................................................99<o:p></o:p>5.2 Réactivité des cycles à six chaînons................................................................ 132<o:p></o:p>5.2.1Points importants à garder à l'esprit .............................................................. 132<o:p></o:p>5.2.2 Réactions typiques..............................................................................133<o:p></o:p>5.2.3 Applications aux hétérocycles d'intérêt – Synthèses multi-étapes.............. 161<o:p></o:p>5.3 Réactivité des anneaux à cinq membres .......................................................167<o:p></o:p>5.3.1 Réactions typiques ................................................................................167<o:p></o:p>5.3.2 Applications aux hétérocycles d'intérêt – Synthèses multi-étapes ......................183<o:p></o:p>5.4 Réactivité des polyhétérocycles contenant à la fois des cycles à cinq et à six chaînons .188<o:p></o:p>Liste des livres et critiques .................................................. .............................................223<o:p></o:p>Annexe Notions de base de nomenclature ou comment trouver la bague structure de son nom .................................227 Abbreviations..................................................................................................................7<o:p></o:p>Chapter 1 Syntheses......................................................................................................11<o:p></o:p>1.1Key-points to remember......................................................................................11<o:p></o:p>1.2Non-metal-catalyzed syntheses........................................................................... 13<o:p></o:p>1.3 Metal-catalyzedsyntheses...................................................................................24<o:p></o:p>Chapter 2 Reactivity of six-membered heterocycles.................................................. 35<o:p></o:p>2.1Key-points to remember ......................................................................................35<o:p></o:p>2.2 Typicalreactions.................................................................................................36<o:p></o:p>2.3Applications to heterocycles of interest – Multi-step syntheses.......................... 53<o:p></o:p>Chapter 3 Reactivity of five-membered heterocycles................................................. 57<o:p></o:p>3.1Key-points to remember......................................................................................57<o:p></o:p>3.2 Typicalreactions.................................................................................................58<o:p></o:p>3.3Applications to heterocycles of interest – Multi-steps syntheses........................ 68<o:p></o:p>Chapter 4 Reactivity of polyheterocycles containing both five<span lang="EN-US" style="font-size:11.0pt;line-height:107%;font-family:"Calibri",sans-serif;mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:"Times New Roman";mso-bidi-theme-font:minor-bidi;mso-ansi-language:EN-US;mso-fareast-language:EN-US;mso-bidi-language:AR-SA">[1]and six-membered rings.....................73<o:p></o:p>4.1Key-points to remember......................................................................................73<o:p></o:p>4.2Reactions.............................................................................................................74<o:p></o:p>Chapter 5 Answers........................................................................................................99<o:p></o:p>5.1Syntheses.............................................................................................................99<o:p></o:p>5.2Reactivity of six-membered rings...................................................................... 132<o:p></o:p>5.2.1Important points to keep in mind.................................................................... 132<o:p></o:p>5.2.2Typical reactions............................................................................................133<o:p></o:p>5.2.3Applications to heterocycles of interest – Multi-step syntheses..................... 161<o:p></o:p>5.3Reactivity of five-Membered rings ....................................................................167<o:p></o:p>5.3.1Typical reactions............................................................................................167<o:p></o:p>5.3.2Applications to heterocycles of interest – Multi-steps syntheses ...................183<o:p></o:p>5.4Reactivity of polyheterocycles containing both five- and six-membered rings .188<o:p></o:p>List of books and reviews...........................................................................................223<o:p></o:p>Appendix Basic notions of nomenclature or how to find out the ring structure from its name........................227 21 00 06 01 https://laboutique.edpsciences.fr/produit/1320/9782759830824/exercise-book-on-aromatic-nitrogen-heterocycles-chemistry 01 00 03 02 https://laboutique.edpsciences.fr/system/product_pictures/data/009/982/875/original/9782759830817-ExerciceBookAromaticNitrogen_couv-sofedis.jpg 17 14 20240913T174029+0200 15 00 03 02 https://laboutique.edpsciences.fr/system/product_pictures/data/009/982/898/original/9782759830817-ExerciceBookAromaticNitrogen_thumbnail.jpg 17 14 20240913T172729+0200 01 P15 EDP Sciences & Science Press 01 01 P15 EDP Sciences & Science Press 04 11 00 20230309 01 00 20230309 19 00 20230309 2026 06 3052868830012 01 WORLD 27 03 9782759830824 15 9782759830824 27 03 9782759830831 15 9782759830831 WORLD 08 EDP Sciences & Science Press 04 01 00 20230309 03 01 D1 EDP Sciences 21 04 05 01 02 1 00 80.00 01 5.50 4.17 EUR laboutique.edpsciences.fr-R001856 03 01 01 R001856 00 ED E107 00 01 01 Exercise book on Aromatic Nitrogen Heterocycles Chemistry How to deal with the synthesis and reactivity of five- and six-membered rings 01 eng 08 232 03 22 10767374 17 01 P15 EDP Sciences & Science Press 01 01 P15 EDP Sciences & Science Press 11 00 20230309 02 01 002220 03 9782759830824 15 9782759830824 03 01 D1 EDP Sciences 45 03 laboutique.edpsciences.fr-002220 03 01 01 002220 03 9782759830824 15 9782759830824 10 EA E107 10 00 01 R001856 ED E107 1 10 01 02 Current Natural Sciences 01 01 Exercise book on Aromatic Nitrogen Heterocycles Chemistry How to deal with the synthesis and reactivity of five- and six-membered rings 1 A01 01 A2104 Sabine Chierici Chierici, Sabine Sabine Chierici Sabine Chierici est enseignant-chercheur au département de chimie moléculaire de l’université Grenoble Alpes. Sabine Chierici is a teacher-researcher in the department of molecular chemistry at the Grenoble Alpes University. 2 A01 01 A2103 Martine Demeunynck Demeunynck, Martine Martine Demeunynck Martine Demeunynck est Directrice de Recherches au CNRS, auDépartement de Pharmacochimie Moléculaire de l'Université Grenoble Alpes.<o:p></o:p> Martine Demeunynck is Director ofResearch at the CNRS, in the Department of Molecular Pharmacochemistry at theGrenoble Alpes University .<o:p></o:p><o:p> </o:p> 01 eng 08 230 03 02 24 Izibook:Subject Chimie 24 Izibook:SubjectAndCategoryAndTags |Chimie| 20 chemistry;exercise;exercises;exercise book;metal catalyzed pathways;five-membered rings;six-membered rings;electrophilic aromatic substitution;organimetallic reaction;complex polycyclic heterocycles 10 2011 SCI013040 01 540 05 06 03 00 <blockquote>Heterocyclic chemistry is one of the largest branches of chemistry. Heterocycles play major roles in important fields such as medicinal and pharmaceutical chemistries, agrochemicals or polymers. A good understanding of the comparative reactivity of simple five- and six-membered rings, i.e. pyrrole vs pyridine type rings, makes it possible to approach or predict the reactivity of more complex heterocycles. This book is a compilation of exercises, mostly adapted from published works. For more clarity we have chosen to limit ourselves to nitrogen containing heterocycles. The book is mainly aimed to Master students, but it will also be of interest for anyone who wants to train in this important field of synthetic chemistry. The book is organized in five sections. In the first chapter, typical syntheses along with metal catalyzed pathways are presented. The two following chapters are devoted to the chemical reactivity of the six-membered (pyridine, quinoline, azines) and five-membered rings (pyrrole, indole, azoles). In these two chapters, the exercises of increasing difficulties focus on the main types of reactions, including electrophilic and nucleophilic aromatic substitutions, N-alkylation and N-arylation, lithiation and other organometallic reactions, and metal catalyzed cross-coupling reactions. In the fourth chapter, the principles discussed in the previous chapters will be applied to the chemistry of complex polycyclic heterocycles containing both five and six membered rings (pyrrolyl-pyridine, aza-indole, indolizine, purine). The exercise solutions are commented in a separate chapter at the end of the book. Basic notions of nomenclature are given in a short appendix, allowing students to find out a ring structure from its name.</blockquote> 02 00 This book is a compilation of exercises, mostly adapted from published works, with commented solutions. The scope is voluntarily limited to nitrogen containing heterocycles. This book is a compilation of exercises, mostly adapted from published works, with commented solutions. The scope is voluntarily  limited to nitrogen containing heterocycles. 04 00 Abréviations.................................................................. .................................................. ...............7<o:p></o:p>Chapitre 1 Synthèses ................................................................ .................................................. ....11<o:p></o:p>1.1Les points-clés à retenir.................................................. .......................................11<o:p></o:p>1.2 Synthèses non catalysées par des métaux ....................................................... 13<o:p></o:p>1.3 Synthèses catalysées par des métaux ........................................................................24<o:p></o:p>Chapitre 2 Réactivité des hétérocycles à six chaînons...................................................... 35<o:p></o:p>2.1Points-clés à retenir ........................................................................................35<o:p></o:p>2.2 Réactions typiques......................................................................................36<o:p></o:p>2.3 Applications aux hétérocycles d'intérêt – Synthèses multi-étapes......................... 53<o:p></o:p>Chapitre 3 Réactivité des hétérocycles à cinq chaînons......................................... ...... 57<o:p></o:p>3.1Points-clés à retenir..............................................................................................57<o:p></o:p>3.2 Réactions typiques............................................................................................58<o:p></o:p>3.3 Applications aux hétérocycles d'intérêt – Synthèses multi-étapes............................ 68<o:p></o:p>Chapitre 4 Réactivité des polyhétérocycles contenant à la fois des cycles à cinq <span lang="EN-US" style="font-size:11.0pt;line-height:107%;font-family:"Calibri",sans-serif;mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:"Times New Roman";mso-bidi-theme-font:minor-bidi;mso-ansi-language:EN-US;mso-fareast-language:EN-US;mso-bidi-language:AR-SA">[1] et à six chaînons.................................73<o:p></o:p>4.1Points-clés à retenir.................................................................................73<o:p></o:p>4.2 Réactions...................................................................74<o:p></o:p>Chapitre 5 Réponses ..................................................................................99<o:p></o:p>5.1Synthèses........................................................................................................99<o:p></o:p>5.2 Réactivité des cycles à six chaînons................................................................ 132<o:p></o:p>5.2.1Points importants à garder à l'esprit .............................................................. 132<o:p></o:p>5.2.2 Réactions typiques..............................................................................133<o:p></o:p>5.2.3 Applications aux hétérocycles d'intérêt – Synthèses multi-étapes.............. 161<o:p></o:p>5.3 Réactivité des anneaux à cinq membres .......................................................167<o:p></o:p>5.3.1 Réactions typiques ................................................................................167<o:p></o:p>5.3.2 Applications aux hétérocycles d'intérêt – Synthèses multi-étapes ......................183<o:p></o:p>5.4 Réactivité des polyhétérocycles contenant à la fois des cycles à cinq et à six chaînons .188<o:p></o:p>Liste des livres et critiques .................................................. .............................................223<o:p></o:p>Annexe Notions de base de nomenclature ou comment trouver la bague structure de son nom .................................227 Abbreviations..................................................................................................................7<o:p></o:p>Chapter 1 Syntheses......................................................................................................11<o:p></o:p>1.1Key-points to remember......................................................................................11<o:p></o:p>1.2Non-metal-catalyzed syntheses........................................................................... 13<o:p></o:p>1.3 Metal-catalyzedsyntheses...................................................................................24<o:p></o:p>Chapter 2 Reactivity of six-membered heterocycles.................................................. 35<o:p></o:p>2.1Key-points to remember ......................................................................................35<o:p></o:p>2.2 Typicalreactions.................................................................................................36<o:p></o:p>2.3Applications to heterocycles of interest – Multi-step syntheses.......................... 53<o:p></o:p>Chapter 3 Reactivity of five-membered heterocycles................................................. 57<o:p></o:p>3.1Key-points to remember......................................................................................57<o:p></o:p>3.2 Typicalreactions.................................................................................................58<o:p></o:p>3.3Applications to heterocycles of interest – Multi-steps syntheses........................ 68<o:p></o:p>Chapter 4 Reactivity of polyheterocycles containing both five<span lang="EN-US" style="font-size:11.0pt;line-height:107%;font-family:"Calibri",sans-serif;mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:"Times New Roman";mso-bidi-theme-font:minor-bidi;mso-ansi-language:EN-US;mso-fareast-language:EN-US;mso-bidi-language:AR-SA">[1]and six-membered rings.....................73<o:p></o:p>4.1Key-points to remember......................................................................................73<o:p></o:p>4.2Reactions.............................................................................................................74<o:p></o:p>Chapter 5 Answers........................................................................................................99<o:p></o:p>5.1Syntheses.............................................................................................................99<o:p></o:p>5.2Reactivity of six-membered rings...................................................................... 132<o:p></o:p>5.2.1Important points to keep in mind.................................................................... 132<o:p></o:p>5.2.2Typical reactions............................................................................................133<o:p></o:p>5.2.3Applications to heterocycles of interest – Multi-step syntheses..................... 161<o:p></o:p>5.3Reactivity of five-Membered rings ....................................................................167<o:p></o:p>5.3.1Typical reactions............................................................................................167<o:p></o:p>5.3.2Applications to heterocycles of interest – Multi-steps syntheses ...................183<o:p></o:p>5.4Reactivity of polyheterocycles containing both five- and six-membered rings .188<o:p></o:p>List of books and reviews...........................................................................................223<o:p></o:p>Appendix Basic notions of nomenclature or how to find out the ring structure from its name........................227 21 00 06 01 https://laboutique.edpsciences.fr/produit/1320/9782759830824/exercise-book-on-aromatic-nitrogen-heterocycles-chemistry 01 00 03 02 https://laboutique.edpsciences.fr/system/product_pictures/data/009/982/875/original/9782759830817-ExerciceBookAromaticNitrogen_couv-sofedis.jpg 17 14 20240913T174029+0200 15 00 03 02 https://laboutique.edpsciences.fr/system/product_pictures/data/009/982/898/original/9782759830817-ExerciceBookAromaticNitrogen_thumbnail.jpg 17 14 20240913T172729+0200 01 P15 EDP Sciences & Science Press 01 01 P15 EDP Sciences & Science Press 04 11 00 20230309 01 00 20230309 19 00 20230309 2026 06 3052868830012 01 WORLD 13 03 9782759830817 15 9782759830817 06 03 9782759830831 15 9782759830831 WORLD 08 EDP Sciences & Science Press 04 01 00 20230309 03 01 D1 EDP Sciences 20 04 05 01 02 1 00 55.99 01 5.50 2.92 EUR 04 06 01 02 1 00 195.99 01 5.50 2.92 EUR 01 04 06 01 02 1 00 214.99 01 5.50 11.21 USD 01 laboutique.edpsciences.fr-002272 03 01 01 002272 03 9782759830831 15 9782759830831 10 EA 10 10 01 02 Current Natural Sciences 01 01 Exercise book on Aromatic Nitrogen Heterocycles Chemistry How to deal with the synthesis and reactivity of five- and six-membered rings 1 A01 01 A2104 Sabine Chierici Chierici, Sabine Sabine Chierici Sabine Chierici est enseignant-chercheur au département de chimie moléculaire de l’université Grenoble Alpes. Sabine Chierici is a teacher-researcher in the department of molecular chemistry at the Grenoble Alpes University. 2 A01 01 A2103 Martine Demeunynck Demeunynck, Martine Martine Demeunynck Martine Demeunynck est Directrice de Recherches au CNRS, auDépartement de Pharmacochimie Moléculaire de l'Université Grenoble Alpes.<o:p></o:p> Martine Demeunynck is Director ofResearch at the CNRS, in the Department of Molecular Pharmacochemistry at theGrenoble Alpes University .<o:p></o:p><o:p> </o:p> 01 eng 08 230 03 02 24 Izibook:Subject Chimie 24 Izibook:SubjectAndCategoryAndTags |Chimie| 20 chemistry;exercise;exercises;exercise book;metal catalyzed pathways;five-membered rings;six-membered rings;electrophilic aromatic substitution;organimetallic reaction;complex polycyclic heterocycles 10 2011 SCI013040 01 540 05 06 03 00 <blockquote>Heterocyclic chemistry is one of the largest branches of chemistry. Heterocycles play major roles in important fields such as medicinal and pharmaceutical chemistries, agrochemicals or polymers. A good understanding of the comparative reactivity of simple five- and six-membered rings, i.e. pyrrole vs pyridine type rings, makes it possible to approach or predict the reactivity of more complex heterocycles. This book is a compilation of exercises, mostly adapted from published works. For more clarity we have chosen to limit ourselves to nitrogen containing heterocycles. The book is mainly aimed to Master students, but it will also be of interest for anyone who wants to train in this important field of synthetic chemistry. The book is organized in five sections. In the first chapter, typical syntheses along with metal catalyzed pathways are presented. The two following chapters are devoted to the chemical reactivity of the six-membered (pyridine, quinoline, azines) and five-membered rings (pyrrole, indole, azoles). In these two chapters, the exercises of increasing difficulties focus on the main types of reactions, including electrophilic and nucleophilic aromatic substitutions, N-alkylation and N-arylation, lithiation and other organometallic reactions, and metal catalyzed cross-coupling reactions. In the fourth chapter, the principles discussed in the previous chapters will be applied to the chemistry of complex polycyclic heterocycles containing both five and six membered rings (pyrrolyl-pyridine, aza-indole, indolizine, purine). The exercise solutions are commented in a separate chapter at the end of the book. Basic notions of nomenclature are given in a short appendix, allowing students to find out a ring structure from its name.</blockquote> 02 00 This book is a compilation of exercises, mostly adapted from published works, with commented solutions. The scope is voluntarily limited to nitrogen containing heterocycles. This book is a compilation of exercises, mostly adapted from published works, with commented solutions. The scope is voluntarily  limited to nitrogen containing heterocycles. 04 00 Abréviations.................................................................. .................................................. ...............7<o:p></o:p>Chapitre 1 Synthèses ................................................................ .................................................. ....11<o:p></o:p>1.1Les points-clés à retenir.................................................. .......................................11<o:p></o:p>1.2 Synthèses non catalysées par des métaux ....................................................... 13<o:p></o:p>1.3 Synthèses catalysées par des métaux ........................................................................24<o:p></o:p>Chapitre 2 Réactivité des hétérocycles à six chaînons...................................................... 35<o:p></o:p>2.1Points-clés à retenir ........................................................................................35<o:p></o:p>2.2 Réactions typiques......................................................................................36<o:p></o:p>2.3 Applications aux hétérocycles d'intérêt – Synthèses multi-étapes......................... 53<o:p></o:p>Chapitre 3 Réactivité des hétérocycles à cinq chaînons......................................... ...... 57<o:p></o:p>3.1Points-clés à retenir..............................................................................................57<o:p></o:p>3.2 Réactions typiques............................................................................................58<o:p></o:p>3.3 Applications aux hétérocycles d'intérêt – Synthèses multi-étapes............................ 68<o:p></o:p>Chapitre 4 Réactivité des polyhétérocycles contenant à la fois des cycles à cinq <span lang="EN-US" style="font-size:11.0pt;line-height:107%;font-family:"Calibri",sans-serif;mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:"Times New Roman";mso-bidi-theme-font:minor-bidi;mso-ansi-language:EN-US;mso-fareast-language:EN-US;mso-bidi-language:AR-SA">[1] et à six chaînons.................................73<o:p></o:p>4.1Points-clés à retenir.................................................................................73<o:p></o:p>4.2 Réactions...................................................................74<o:p></o:p>Chapitre 5 Réponses ..................................................................................99<o:p></o:p>5.1Synthèses........................................................................................................99<o:p></o:p>5.2 Réactivité des cycles à six chaînons................................................................ 132<o:p></o:p>5.2.1Points importants à garder à l'esprit .............................................................. 132<o:p></o:p>5.2.2 Réactions typiques..............................................................................133<o:p></o:p>5.2.3 Applications aux hétérocycles d'intérêt – Synthèses multi-étapes.............. 161<o:p></o:p>5.3 Réactivité des anneaux à cinq membres .......................................................167<o:p></o:p>5.3.1 Réactions typiques ................................................................................167<o:p></o:p>5.3.2 Applications aux hétérocycles d'intérêt – Synthèses multi-étapes ......................183<o:p></o:p>5.4 Réactivité des polyhétérocycles contenant à la fois des cycles à cinq et à six chaînons .188<o:p></o:p>Liste des livres et critiques .................................................. .............................................223<o:p></o:p>Annexe Notions de base de nomenclature ou comment trouver la bague structure de son nom .................................227 Abbreviations..................................................................................................................7<o:p></o:p>Chapter 1 Syntheses......................................................................................................11<o:p></o:p>1.1Key-points to remember......................................................................................11<o:p></o:p>1.2Non-metal-catalyzed syntheses........................................................................... 13<o:p></o:p>1.3 Metal-catalyzedsyntheses...................................................................................24<o:p></o:p>Chapter 2 Reactivity of six-membered heterocycles.................................................. 35<o:p></o:p>2.1Key-points to remember ......................................................................................35<o:p></o:p>2.2 Typicalreactions.................................................................................................36<o:p></o:p>2.3Applications to heterocycles of interest – Multi-step syntheses.......................... 53<o:p></o:p>Chapter 3 Reactivity of five-membered heterocycles................................................. 57<o:p></o:p>3.1Key-points to remember......................................................................................57<o:p></o:p>3.2 Typicalreactions.................................................................................................58<o:p></o:p>3.3Applications to heterocycles of interest – Multi-steps syntheses........................ 68<o:p></o:p>Chapter 4 Reactivity of polyheterocycles containing both five<span lang="EN-US" style="font-size:11.0pt;line-height:107%;font-family:"Calibri",sans-serif;mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:"Times New Roman";mso-bidi-theme-font:minor-bidi;mso-ansi-language:EN-US;mso-fareast-language:EN-US;mso-bidi-language:AR-SA">[1]and six-membered rings.....................73<o:p></o:p>4.1Key-points to remember......................................................................................73<o:p></o:p>4.2Reactions.............................................................................................................74<o:p></o:p>Chapter 5 Answers........................................................................................................99<o:p></o:p>5.1Syntheses.............................................................................................................99<o:p></o:p>5.2Reactivity of six-membered rings...................................................................... 132<o:p></o:p>5.2.1Important points to keep in mind.................................................................... 132<o:p></o:p>5.2.2Typical reactions............................................................................................133<o:p></o:p>5.2.3Applications to heterocycles of interest – Multi-step syntheses..................... 161<o:p></o:p>5.3Reactivity of five-Membered rings ....................................................................167<o:p></o:p>5.3.1Typical reactions............................................................................................167<o:p></o:p>5.3.2Applications to heterocycles of interest – Multi-steps syntheses ...................183<o:p></o:p>5.4Reactivity of polyheterocycles containing both five- and six-membered rings .188<o:p></o:p>List of books and reviews...........................................................................................223<o:p></o:p>Appendix Basic notions of nomenclature or how to find out the ring structure from its name........................227 21 00 06 01 https://laboutique.edpsciences.fr/produit/1320/9782759830824/exercise-book-on-aromatic-nitrogen-heterocycles-chemistry 01 00 03 02 https://laboutique.edpsciences.fr/system/product_pictures/data/009/982/875/original/9782759830817-ExerciceBookAromaticNitrogen_couv-sofedis.jpg 17 14 20240913T174029+0200 15 00 03 02 https://laboutique.edpsciences.fr/system/product_pictures/data/009/982/898/original/9782759830817-ExerciceBookAromaticNitrogen_thumbnail.jpg 17 14 20240913T172729+0200 01 P15 EDP Sciences & Science Press 01 01 P15 EDP Sciences & Science Press 08 11 00 20230309 01 00 20230309 19 00 20230309 2026 06 3052868830012 01 WORLD 13 03 9782759830817 15 9782759830817 06 03 9782759830824 15 9782759830824 WORLD 08 EDP Sciences & Science Press 08 01 00 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